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⇓    Provigil    ⇓

Active Ingredient: Modafinil

Other names for this medication:
Modalert, Modvigil

It is believed that such pharmaceutical preparations can significantly improve memory functions, concentration of attention, and also have a stimulating effect on the nervous system, allowing to increase efficiency and at the time to get rid of the need for sleep.
Among a very large group of nootropics of particular interest is Modafinil

The primary characteristic of the psychostimulant
Modafinil is a psychostimulant developed in the seventies of the twentieth century. The authorship of this money belongs to the French-American manufacturer – the Cephalon corporation, which was looking for an effective tool for combating narcolepsy. Despite the fact that according to statistics such a disease is quite rare (diagnosed in the order of 0.025% of the US population), a person suffering from it can fall asleep unnoticeably while driving a vehicle or in another situation requiring high concentration of attention. Therefore, the problem is much more serious than it may seem at first glance, and requires competent treatment. The US Central Office for Quality Control of Medicines and Food Products (FDA) considers Modafinil a relatively safe pharmaceutical product, which is a great alternative to caffeine, amphetamine and other popular stimulants of synthetic origin. In the drug, in addition to the main active substance (modafinil), there are a number of auxiliary components.

Pharmacological profile
Today, little is known about the exact mechanism of modafinil exposure to the human body. As a result of large-scale clinical studies, scientists have determined that the drug increases the level of serotonin in the anterior cortex and amygdala and stimulates an increased ejection from synoptic gaps of dopamine, norepinephrine and other monoamines. Under the influence of a medicament, the hypothalamus intensively produces histamine, which entails the activation of alpha-1 receptors. Modafinil affects different parts of the brain. One of the most important and pronounced effects is considered to be an increase in vivacity, concentration of attention, the ability to memorize, comprehend and assimilate new information. With the help of medicine, a person is able to control his arbitrary attention, as well as improve the perception of the surrounding reality. Although Modafinil is not an antidepressant and does not cause euphoria like some other forbidden stimulants, it can easily return a good mood and reduce anxiety.

Scope of application
As mentioned above, initially Modafinil was developed as an effective remedy for narcolepsy and obstructive sleep apnea. It was supposed to involve him also in order to get rid of the chronic lack of sleep and drowsiness resulting from the transition to summer / winter time and the consequent shifts in the working schedule. Unlike amphetamine, which causes euphoria, as well as side effects in the form of a hangover and addiction, Modafinil is able to significantly increase concentration of attention, vigor and efficiency without “pobochek.” For experimental purposes, the drug was used and continues to be used to this day for military and space missions. Scientists from Canada have published a detailed report that nootropics managed to demonstrate very positive results during the long stay of an astronaut group on the ISS. In the US Army, the use of Provigil by pilots of fighter jets and military helicopters is permissible, which allows them to maintain a high degree of concentration of attention until one and a half days after a single dose of 600 mg and more.
Some scientists have suggested that the drug can be used to treat dependence on cocaine and some other addictive stimulants. A double-seated study involving patients suffering from a similar problem showed that the drug is able to alleviate the cocaine withdrawal, but a positive result is not guaranteed and depends on a number of psycho-emotional and other co-factors.
Based on the results of numerous clinical trials, it was possible to establish that the drug reduces appetite and promotes intensive weight loss. Amphetamine, taken for similar purposes, significantly increases the pulse rate, can cause tachycardia and a number of other undesirable effects.
Modafinil also demonstrates outstanding results in the therapy of cognitive impairment, is used to improve memory and eliminates excessive daytime fatigue and drowsiness, which are caused by primary biliary cirrhosis.
Tablets with a higher dose of the main active ingredient have been used since 2004 to treat adolescents and children suffering from hyperactivity and attention deficit disorder.
Provigil and its analogues are currently used to alleviate the symptoms of multiple sclerosis, such as neurological fatigue and depressive conditions.
After clinical trials of the R-isomer Modafinil, it has proved very positive as an effective tool for the treatment of bipolar affective disorder.


Use of the medicine is prohibited in the following cases: ↴
➲ individual intolerance or hypersensitivity to the constituent components;
➲ suffered vascular or cardiac diseases;
➲ the presence of phobias, nervous disorders and obsessive depressive states.
Use of Provigil is contraindicated in pregnancy and during lactation. The medication is not combined with alcoholic beverages and can significantly reduce the effectiveness of contraceptives. With cirrhosis and severe liver damage, the drug is strictly prohibited.

It is also necessary to know that Alertec gives a positive result in the case of passing the doping control before the sports competitions. ◀

Application features – recommended dosages
To treat drowsiness and narcolepsy, the drug is used once a day in the morning in the amount of 200-300 mg. Dosage of 400 mg can lead to difficulties with night falling asleep. In studies in which pilots of aircraft and helicopters took part, a dosage of 600 mg, divided into several receptions, allowed to maintain high accuracy, good reaction and concentration for one and a half days.
In the case of patients suffering from multiple sclerosis, an increase in the dose from 200 to 400 mg did not show a significant difference in the results.

Overdose and side effects
The most common side effects that occur with an overdose of the drug are headache and nausea.

 To date, Provigil is considered a safer stimulant than amphetamine and even caffeine. However, according to a large-scale study by the Canadian Ministry of Health, it was possible to establish such information regarding side effects and possible complications:
➢ the use of the drug is contraindicated for persons suffering from a clinically significant prolapse of the mitral valve, developed on the basis of using stimulants;
➢ It is forbidden to use nootropics in the event of various mental disorders and abnormalities;
➢ increased sensitivity to the components of the drug can trigger rash, dermatitis, necrosis of toxic type and a number of skin reactions that threaten life;
➢ medication can cause shortness of breath, a feeling of heat, the occurrence of ulcers in the mouth and urticaria.

In rare cases, an overdose can lead to anaphylactic shock, disseptic disorders, nasal congestion, low back pain and Quincke’s swelling. Provigil should not be used by children, despite the fact that the results of the studies demonstrated the relative safety of the drug for adolescents and children aged 9 to 17 years.

About advantages and disadvantages
Modafinil has a minimal number of side effects with a palpable effect, which is expressed in increasing efficiency, improving concentration and lack of need for sleep.
That is why today many military departments of different countries are raising the question of the complete replacement of the traditional Amphetamine, present in the first-aid kit of fighters of special units, with Modafinil. Due to its outstanding qualities, the drug is actively used among cosmonauts, pilots and even law enforcement officers.
For example, in some US states, policemen receive 200 mg of Modalert daily to increase productivity and improve the response needed to capture criminals. On the other hand, in cases of abuse or excess dosage can be observed: dehydration, diarrhea, vomiting, nausea and a number of other unpleasant symptoms.

Since this pharmaceutical agent raises the level of histamine, it is better to abstain from using it for people prone to allergic reactions. Buyers from some countries also include a high cost of the drug and a certain complexity associated with its purchase.

Interesting Facts
Modafinil and its analogs are used today in bodybuilding. Among fans of weightlifting there is an opinion that the drug not only increases IQ, but also miraculously increases the efficiency from the gym. In fact, it allows you to ensure the maximum level of concentration, allowing you to concentrate on the training process.
The active component of the drug is part of various pre-training complexes designed to improve performance and “pumping”. Modalert and Provigil are also often used by American and European students, because with their help you can prepare for the surrender of the session in a matter of days, and the assimilation of information is much more effective.

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